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KMID : 0380420150390020058
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Journal of Prventive Veterinary Medicine
2015 Volume.39 No. 2 p.58 ~ p.64
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Distribution and bioaccumulation of Lu177-labeled hydrophobically modified glycol chitosan in ICR mice
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Lee Jung-Su
Ji Hyeong-Jin
Chai Hee-Youl
Jeong Jae-Hwang
Nam Sang-Yoon
Yun Young-Won
Lee Beom-Jun
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Abstract
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This study was conducted to evaluate the accumulation and distribution of HGC (hydrophobically modified glycol chitosan) as a degradable nanoparticle in the body. To determine the movement of degradable HGC nanoparticles in the body, 20 mg/kg of lutetium177-labeled HGC (Lu177-HGC) with a size range from 320 to 400 nm was injected intravenously into ICR mice, and the amount of radioactivity remaining in blood and several organs was measured at various time points a period of 5 days. In the pharmacokinetics analysis using the Lu177 radioisotope, the free Lu177 was mainly distributed and accumulated in the order of kidney>liver>lung at 1 day after the injection of radioisotope. However, the Lu177-HGC showed a high distribution of nanoparticles in the order of liver>spleen>kidney until 5 days. These results would provide a basic pharmacokinetics for the use of HGC as a drug carrier in drug delivery system.
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KEYWORD
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hydrophobically modified glycol chitosan, radioisotope, luterium radioactivity
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